Individual and Environmental Factors Associated with Infection Due to Cryptococcus neoformans Serotype D
Identifieur interne : 001E74 ( Main/Exploration ); précédent : 001E73; suivant : 001E75Individual and Environmental Factors Associated with Infection Due to Cryptococcus neoformans Serotype D
Auteurs : Françoise Dromer [France] ; Simone Mathoulin [France] ; Bertrand Dupont [France] ; Luc Letenneur [France] ; Olivier Ronin [France]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 1996-07.
Abstract
Differences between the two varieties of Cryptococcus neoformans with regard to geographic distribution, epidemiology, and even pathogenicity have been described. None between C. neoformans variety neoformans serotypes A and D have been reported. We reviewed 452 cases of cryptococcosis diagnosed in France, where serotype D is responsible for 21% of the infections. Univariate analysis showed that the frequency of serotype D infections was significantly higher among patients >60 years of age, those born in Europe, those receiving corticosteroid therapy, and those who had skin lesions. In the multivariate analysis, the risk of serotype D infection was significantly higher for patients with skin lesions, those receiving corticosteroid therapy, and those living in certain regions in France. It was significantly lower for patients with meningitis, those coming from Africa, and females. Among the 350 human immunodeficiency virus-infected patients, the risk was significantly higher for those >60 years old, those who were intravenous drug abusers, and those with skin lesions. The risk was significantly lower for patients from Africa and in cases of meningitis. These results suggest that individual and environmental factors can be associated with the serotype of the infecting strain of C. neoformans.
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DOI: 10.1093/clinids/23.1.91
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wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre National de Référence des Mycoses et des Antifongiques, Institut Pasteur</wicri:orgArea></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Reprints or correspondence: Dr. Françoise Dromer, Centre National de Référence des Mycoses et des Antifongiques, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mathoulin, Simone" sort="Mathoulin, Simone" uniqKey="Mathoulin S" first="Simone" last="Mathoulin">Simone Mathoulin</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" 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Institut Pasteur</wicri:orgArea></affiliation></author><author><name sortKey="Ronin, Olivier" sort="Ronin, Olivier" uniqKey="Ronin O" first="Olivier" last="Ronin">Olivier Ronin</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre National de Référence des Mycoses et des Antifongiques, Institut Pasteur</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="1996-07">1996-07</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="91">91</biblScope><biblScope unit="page" to="96">96</biblScope></imprint><idno type="ISSN">1058-4838</idno></series><idno type="istex">49F2C660DBC10E3CB1E8F3EFFD76643A31E71916</idno><idno type="DOI">10.1093/clinids/23.1.91</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Differences between the two varieties of Cryptococcus neoformans with regard to geographic distribution, epidemiology, and even pathogenicity have been described. None between C. neoformans variety neoformans serotypes A and D have been reported. We reviewed 452 cases of cryptococcosis diagnosed in France, where serotype D is responsible for 21% of the infections. Univariate analysis showed that the frequency of serotype D infections was significantly higher among patients >60 years of age, those born in Europe, those receiving corticosteroid therapy, and those who had skin lesions. In the multivariate analysis, the risk of serotype D infection was significantly higher for patients with skin lesions, those receiving corticosteroid therapy, and those living in certain regions in France. It was significantly lower for patients with meningitis, those coming from Africa, and females. Among the 350 human immunodeficiency virus-infected patients, the risk was significantly higher for those >60 years old, those who were intravenous drug abusers, and those with skin lesions. The risk was significantly lower for patients from Africa and in cases of meningitis. These results suggest that individual and environmental factors can be associated with the serotype of the infecting strain of C. neoformans.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Dromer, Francoise" sort="Dromer, Francoise" uniqKey="Dromer F" first="Françoise" last="Dromer">Françoise Dromer</name></region><name sortKey="Dromer, Francoise" sort="Dromer, Francoise" uniqKey="Dromer F" first="Françoise" last="Dromer">Françoise Dromer</name><name sortKey="Dupont, Bertrand" sort="Dupont, Bertrand" uniqKey="Dupont B" first="Bertrand" last="Dupont">Bertrand Dupont</name><name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name><name sortKey="Mathoulin, Simone" sort="Mathoulin, Simone" uniqKey="Mathoulin S" first="Simone" last="Mathoulin">Simone Mathoulin</name><name sortKey="Ronin, Olivier" sort="Ronin, Olivier" uniqKey="Ronin O" first="Olivier" last="Ronin">Olivier Ronin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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